Hello, my name is Tom and I'm a domestic economy redeemer. You've heard of people like me? Well, I'm one of them. Really.
I'm more than delighted to redeem AA miles for a $450-$500 domestic roundtrip, a trip I have to take anyway. I consequently value AA miles at maybe something like 1.5 cents and, absolutely yes, I wouldn't dream of using a miles card for ordinary daily 1x spending. That's why God, or Citi anyway, created the Double Cash card (2% cash back).
The consequence of the foregoing means that the Prestige, with its 1.6 cents per point and its 3x bonus categories, essentially combines with the Double Cash card to squeeze out mileage cards completely. In other words, for me it's the Double Cash for daily unbonused spending and the Prestige for air/hotel spending at 3x. (Citi also gives me an annual 25% points bonus.) There's no room for anything else, analytically speaking.
The other key point here is that efficient miles usage requires the finding of "saver" space while TYP usage for an AA ticket is an "any ticket/any time" redemption.
That's the simplified version of what I do.
I'll leave Amex points and short-haul Avios redemption on AA for another day since, as Travis has already noted, when you really dive into this stuff the analysis can get somewhat involved.